منابع مشابه
ROCK and Rho in 3D
In This Issue In This Issue BMP in a hairy situation morphogen must be both off and on for hairs to grow, according to Kobielak et al. on page 609. Their studies of bald mice reveal that bone morphogenetic protein (BMP) controls the switch from dividing to differentiating hair cells by working at the right time and place. Hair cells arise from a pool of epithelial precursors that first prolifer...
متن کاملROCK and Rho will never Dia
In This Issue In This Issue ROCK and Rho will never Dia irectional migration of a cell requires both lamellipodia formation at the leading edge and actomyosin contraction within the tail. New results from Tsuji et al. (page 819) indicate that Rho may mediate both tasks, and that these two arms of Rho signaling are antagonistic. Rho signaling is known to mediate the formation of stress fibers, s...
متن کاملRock 'n' Rho: regulation of ion channels.
THE SMALL GTPase Rho has three isoforms, RhoA, RhoB, and RhoC, of which RhoA has been widely studied. When the Rho gene was first cloned in 1980s, the physiological function of Rho was thought to be similar to its relatives, the Ras proteins. Unexpectedly, Rho was soon found to be crucial in the regulation of the actin cytoskeleton (10, 11). In the following years, many Rho downstream targets w...
متن کاملCancer Stem Cells and Radioresistance: Rho/ROCK Pathway Plea Attention
Radiation is the most potent mode of cancer therapy; however, resistance to radiation therapy results in tumor relapse and subsequent fatality. The cancer stem cell (CSC), which has better DNA repair capability, has been shown to contribute to tumor resistance and is an important target for treatment. Signaling molecules such as Notch, Wnt, and DNA repair pathways regulate molecular mechanisms ...
متن کاملRho, ROCK and actomyosin contractility in metastasis as drug targets
Metastasis is the spread of cancer cells around the body and the cause of the majority of cancer deaths. Metastasis is a very complex process in which cancer cells need to dramatically modify their cytoskeleton and cope with different environments to successfully colonize a secondary organ. In this review, we discuss recent findings pointing at Rho-ROCK or actomyosin force (or both) as major dr...
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ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 2015
ISSN: 0002-9440
DOI: 10.1016/j.ajpath.2015.01.005